Figure 1.

Identification of the peptide core sequence to p206–220-specific T cell hybridomas. T cell hybridomas were stimulated with 5 μg/ml wild-type or variant peptides for 48 hr. The ability of the hybridomas to respond to antigen was assessed on the basis of the level of IL-2 production, as detected by ELISA. The stimulation index is the ratio of IL-2 level from culture supernatants with peptides to that of culture supernatants without peptides. The underlined sequence represents the peptide core sequence of that epitope.