Table 4.

Relative binding capacity of GAD65 immunogenic epitopes to I-A^g7 and I-A^g7.PD class II molecules

Peptide	Immunogenic epitope of	Binding
		To I-Ag7	To I-Ag7.PD
206–220	g7	+++	−
221–235	g7	++++	++++
286–300	g7	++++	+
401–415	g7	++++	+++
561–575	g7	+	+
456–470	PD	+	++++
331–345	PD	+	++++
551–565	PD	−	++

++++, 50% inhibition obtained with 0–50 μM inhibitory peptide; +++, 50% inhibition obtained with 51–250 μM inhibitory peptide; ++, 50% inhibition obtained with 251–500 μM inhibitory peptide; +, 50% inhibition obtained with greater than 501 μM inhibitory peptide; −, no inhibition detected.