Abstract
The interferon system of 20 children aged 2 to 11 years (mean 5 years), diagnosed as having transient synovitis of the hip by clinical criteria, was studied. The mean blood interferon concentration was significantly higher than that of normal children, and the incidence of an antiviral state of cells (in 78% of patients) was also significantly higher than in the control group. These findings are compatible with the hypothesis that the aetiology of transient synovitis is an acute, possibly unusual, viral infection.
Full text
PDFSelected References
These references are in PubMed. This may not be the complete list of references from this article.
- Aviel A., Hahn T., Levin S., Ostfeld E., Bregman V., Marshak G. Interferon anti-viral system in Bell's palsy. Acta Otolaryngol. 1983 Jan-Feb;95(1-2):69–73. doi: 10.3109/00016488309130917. [DOI] [PubMed] [Google Scholar]
- Blockey N. J., Porter B. B. Transient synovitis of hip. A virological investigation. Br Med J. 1968 Nov 30;4(5630):557–558. doi: 10.1136/bmj.4.5630.557. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Illingworth C. M. 128 limping children with no fracture, sprain, or obvious cause. Seven were found to have Perthes' disease, 76 seemed to have transient synovitis of the hip, and in 45 the cause seemed to be in the ankle or knee. Clin Pediatr (Phila) 1978 Feb;17(2):139–142. doi: 10.1177/000992287801700207. [DOI] [PubMed] [Google Scholar]
- Jacobs B. W. Synovitis of the hip in children and its significance. Pediatrics. 1971 Mar;47(3):558–566. [PubMed] [Google Scholar]
- LITTLE J., BRUCE J., ANDREWS H., CRAWFORD K., McKINLEY G. Treatment of disseminated infantile histoplasmosis with amphotericin B. Pediatrics. 1959 Jul;24(1):1–6. [PubMed] [Google Scholar]
- Levin S., Hahn T. Evaluation of the human interferon system in viral disease. Clin Exp Immunol. 1981 Dec;46(3):475–483. [PMC free article] [PubMed] [Google Scholar]
- Levin S. Interferon in acute viral infections. Eur J Pediatr. 1983 Mar;140(1):2–4. doi: 10.1007/BF00661894. [DOI] [PubMed] [Google Scholar]
- Sharwood P. F. The irritable hip syndrome in children. A long-term follow-up. Acta Orthop Scand. 1981 Dec;52(6):633–638. doi: 10.3109/17453678108992159. [DOI] [PubMed] [Google Scholar]