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. 1999 Aug 3;96(16):9311–9316. doi: 10.1073/pnas.96.16.9311

Figure 3.

Figure 3

Immunological properties of NRP. (A) Proliferation of CTLp from 8.3-NOD and NOD/Lt mice in response to NOD islet-cells (Left) or NOD splenocytes pulsed with NRP or tum (Right) (P < 0.05 for islet cell- or NRP- vs. tum-induced proliferation of 8.3-CTLp, and NRP-induced proliferation of 8.3-CTLp vs. NOD/Lt T cells). (B) Cytokine secretion by 8.3-CTLp in response to NOD islet cells or splenocytes pulsed with 1 μg/ml of NRP or tum (Center and Right) (P < 0.009 for IFN-γ/IL-2 secretion induced by NRP vs. tum). (C) Differentiation of 8.3-CTLp from RAG-2−/− 8.3-NOD mice into CTL. The panel shows 51Cr-release assays by using NRP- or tum-pulsed RMA-SKd cells (Left and Center) or NOD or B6 islet cells as targets, at a 1:10 target/effector ratio (Right) (P < 0.05 for NRP vs. tum reactivity or NOD vs. B6 islet cell reactivity).