Figure 9.
Interleukin (IL)-4 or IL-4/prednisolone (Pred) treatment is associated with reduced anticollagen type II (CII) antibody levels. Treatment with 1 μg/day IL-4 resulted in lower anticollagen type II antibodies. Total Immunoglobulins (Ig tot), IgG1 and IgG2a levels were reduced. Similar effects were found after treatment with IL-4/prednisolone (1 μg per day/0.05 mg per kg). Anticollagen type II levels were determined in at least six mice per group. Data are expressed as means ± standard deviation dilution, which gives the half maximal value.