Abstract
Serum samples from 145 children with no known immunosuppressive illness were examined by indirect immunofluorescence for antibody to Pneumocystis carinii. Positive antibody titres (greater than or equal to 1:8 dilution) were found in 69 children (48%). Antibody could not be detected in the remaining children. Previous studies have shown that at least 75% of children have antibodies to P. carinii by the age of 4 years. This study shows a lower percentage of children with detectable antibody. This may be related to geographical variation of antigen or possibly to the widespread use of co-trimoxazole.
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Selected References
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- Hughes W. T., Kuhn S., Chaudhary S., Feldman S., Verzosa M., Aur R. J., Pratt C., George S. L. Successful chemoprophylaxis for Pneumocystis carinii pneumonitis. N Engl J Med. 1977 Dec 29;297(26):1419–1426. doi: 10.1056/NEJM197712292972602. [DOI] [PubMed] [Google Scholar]
- Hughes W. T. Natural mode of acquisition for de novo infection with Pneumocystis carinii. J Infect Dis. 1982 Jun;145(6):842–848. doi: 10.1093/infdis/145.6.842. [DOI] [PubMed] [Google Scholar]
- Meuwissen J. H., Tauber I., Leeuwenberg A. D., Beckers P. J., Sieben M. Parasitologic and serologic observations of infection with Pneumocystis in humans. J Infect Dis. 1977 Jul;136(1):43–49. doi: 10.1093/infdis/136.1.43. [DOI] [PubMed] [Google Scholar]
- Pifer L. L., Hughes W. T., Stagno S., Woods D. Pneumocystis carinii infection: evidence for high prevalence in normal and immunosuppressed children. Pediatrics. 1978 Jan;61(1):35–41. [PubMed] [Google Scholar]
- Price R. A., Hughes W. T. Histopathology of Pneumocystis carinii infestation and infection in malignant disease in childhood. Hum Pathol. 1974 Nov;5(6):737–752. doi: 10.1016/s0046-8177(74)80043-2. [DOI] [PubMed] [Google Scholar]
- Shepherd V., Jameson B., Knowles G. K. Pneumocystis carinii pneumonitis: a serological study. J Clin Pathol. 1979 Aug;32(8):773–777. doi: 10.1136/jcp.32.8.773. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Siegel S. E., Nesbit M. E., Baehner R., Sather H., Hammond G. D. Pneumonia during therapy for childhood acute lymphoblastic leukemia. Am J Dis Child. 1980 Jan;134(1):28–34. doi: 10.1001/archpedi.1980.02130130020007. [DOI] [PubMed] [Google Scholar]