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. 1999 Aug 3;96(16):9385–9390. doi: 10.1073/pnas.96.16.9385

Figure 1.

Figure 1

Change in BDNF mRNA and protein levels in L4 and L5 DRGs and lumbar dorsal horn. (A) Northern blots for BDNF and cyclophilin mRNA in L4 and L5 DRGs showing increased BDNF mRNA after stimulation of the sciatic nerve at C- but not A-fiber strength and 24 h after inflammation of the hindpaw. (B) BDNF protein levels, measured by ELISA, in L4 and L5 DRGs (n = 6) in naïve and inflamed rats (48 h post-CFA). Inflammation increased BDNF in the ipsilateral DRG (P < 0.01), which was prevented by anti-NGF (P < 0.01). (C) The elevation of BDNF in the dorsal horn 48 h after inflammation (n = 6, P < 0.05) also was prevented by anti-NGF pretreatment (n = 6, P < 0.05).