Table 1.
Genotype frequencies of Fc receptor-like 3(FCRL3) single nucleotide polymorphisms in rheumatoid arthritis cases, in controls and in subgroups
| Single nucleotide polymorphism | Controls | Cases | Two-copy shared epitope allelesb | Rheumatoid factor-positive a, c | |
| Controls | Cases | ||||
| FCRL3-169*C/T (fclr3_3, rs7528684) | |||||
| T/T | 595 (28.7) | 324 (30.4) | 45 (36.9) | 71 (32.0) | 324 (30.4) |
| C/T | 1055 (50.9) | 524 (49.2) | 52 (42.6) | 103 (46.4) | 524 (49.2) |
| C/C | 423 (20.4) | 217 (20.4) | 25 (20.5) | 48 (21.6) | 217 (20.4) |
| P value | 0.57 | 0.69 | 0.57 | ||
| FCRL3-169*C/T (fclr3_4, rs11264799) | |||||
| 1/1 | 258 (53.3) | 404 (53.1) | 13 (50.0) | 132 (52.6) | 404 (53.1) |
| 1/2 | 190 (39.3) | 296 (38.9) | 10 (38.5) | 95 (37.8) | 296 (38.9) |
| 2/2 | 36 (7.4) | 61 (8.0) | 3 (11.5) | 24 (9.6) | 61 (8.0) |
| P value | 0.93 | 0.94 | 0.93 | ||
| FCRL3-169*C/T (fclr3_5, rs945635) | |||||
| 1/1 | 123 (27.9) | 209 (28.4) | 9 (36.0) | 64 (27.3) | 209 (28.4) |
| 1/2 | 200 (45.3) | 362 (49.3) | 12 (48.0) | 116 (49.6) | 362 (49.3) |
| 2/2 | 118 (26.8) | 164 (22.3) | 4 (16.0) | 54 (23.1) | 164 (22.3) |
| P value | 0.46 | 0.57 | 0.46 | ||
| FCRL3-169*C/T (fclr3_6, rs3761959) | |||||
| 1/1 | 124 (26.3) | 209 (27.8) | 8 (30.8) | 65 (27.1) | 209 (27.8) |
| 1/2 | 220 (46.7) | 370 (49.3) | 12 (46.1) | 120 (50.0) | 370 (49.3) |
| 2/2 | 127 (27.0) | 172 (22.9) | 6 (23.1) | 55 (22.9) | 172 (22.9) |
| P value | 0.28 | 0.91 | 0.28 | ||
Data presented as n (%). aComparison group = all controls. bSubgroup stratified by two copies of shared epitope alleles. cSubgroup stratified by the presence of rheumatoid factor (measured cumulatively).