Table 3.
MHC2TA genotype and allele frequencies in the Austrian and Swedish study populations
| Austrian cohort | Swedish cohort [12] | |||||
| RA patients (n = 362) | Matched controls (n = 351) | Additional controls (n = 1,709) | RA patients (n = 1262) | Matched controls (n = 704) | Additional controls (n = 1,599) | |
| MHC2TA -168 AA genotype | 184 (50.8)* | 172 (49.0)† | 894 (52.3)‡ | 728 (57.7) | 449 (63.8) | 989 (61.9) |
| MHC2TA -168 AG genotype | 155 (42.8) | 142 (40.5) | 669 (39.1) | 451 (35.7) | 221 (31.4) | 528 (33.0) |
| MHC2TA -168 GG genotype | 23 (6.4) | 37 (10.5) | 146 (8.5) | 83 (6.6) | 34 (4.8) | 82 (5.1) |
| MHC2TA -168G allele frequency | 0.278 | 0.308 | 0.281 | 0.244 | 0.205 | 0.216 |
The MHC2TA genotype and allele frequencies of the present study population and the primary report by Swanberg and colleagues [12]. Carriers of a -168G allele were less frequent in the Austrian cohort compared with the Swedish cohort. *Austrian rheumatoid arthritis (RA) patients versus Swedish RA patients, P = 0.02, †Austrian matched controls versus Swedish matched controls, P < 0.001, ‡Austrian additional controls versus Swedish additional controls, P < 0.001.