Table 1.
Group | Score | Mean ± SEM | P value |
Control dendritic cells | 3, 3, 4, 3, 3.5, 3 | 3.250 ± 0.171 | |
LF 15-0195-treated dendritic cells | 1, 0, 1.5, 1, 1.5, 1 | 1.000 ± 0.224 | 0.000283 |
Histopathologic changes are scored using the following parameters. Synovial inflammation (infiltration and hyperplasia) is scored on a scale from 0 to 4, depending on the amount of inflammatory cells in the synovial cavity (exudates) and synovial tissues (infiltrate). Each joint is scored separately by two individuals unaware of the treatment protocol, using the following scale: no inflammation = 0; slight thickening of lining layer and/or some infiltrating cells in the sublining layer = 1–2; thickening of lining layer and/or a more pronounced influx of cells in the sublining layer = 3; and presence of cells in the synovial space, thickening of lining layer, and synovium highly infiltrated with numerous inflammatory cells = 4.