Table 1.
Clinicopathological characteristics and gene expression variation of each patient
| Difference in gene expression between CB and ST (ΔCt [GeneST] – ΔCt [GeneCB]) | ||||||||||
| Patient number | Age | Time between CB and ST (days) | Histology | Tumor diameter (cm) | Grade | Lymph node involvement | Correlation (rs) between paired CB and ST | PAI-1 | COX-2 | ERBB2 |
| 1 | 68 | 7 | Ductal | 3.3 | 3 | Negative | 0.97 | -0.39 | -0.15 | -0.08 |
| 2 | 59 | 8 | Ductal | 1.8 | 3 | Negative | 0.98 | -1.68 | -0.20 | 0.52 |
| 3 | 49 | 21 | Ductal | 3.3 | 2 | Positive | 0.98 | -1.19 | -1.03 | 0.62 |
| 4 | 57 | 13 | Ductal | 1.1 | 1 | Positive | 0.89 | -0.63 | 0.61 | -0.02 |
| 5 | 63 | 14 | Ductal | 9.0 | 2 | Negative | 0.97 | -1.41 | -1.80 | 1.40 |
| 6 | 60 | 21 | Ductulo-lobular | 2.7 | 1 | Positive | 0.98 | -1.38 | -2.41 | 0.23 |
| 7 | 80 | 12 | Ductal | 3.1 | 1 | Positive | 0.95 | -2.62 | -1.39 | 0.44 |
| 8 | 81 | 14 | Lobular | 2.8 | 2 | Positive | 0.94 | -3.78 | -3.73 | 0.29 |
| 9 | 34 | 14 | Ductal | 1.8 | 2 | Negative | 0.95 | -3.16 | -1.37 | 0.12 |
| 10 | 68 | 10 | Ductal | 0.9 | 2 | Micrometastasis | 0.87 | -3.57 | -7.27 | 1.01 |
| 11 | 65 | 16 | Lobular | 1.9 | 1 | Negative | 0.89 | -5.16 | -0.80 | -0.02 |
| 12 | 80 | 13 | Ductal | 6.0 | 3 | Positive | 0.86 | -2.16 | -0.20 | 0.63 |
| 13 | 59 | 2 | Apocrine | 2.7 | 3 | Negative | 0.98 | -1.18 | -4.64 | -0.27 |
| 14 | 73 | 12 | Lobular | 1.9 | 2 | Positive | 0.95 | -4.60 | -3.97 | -1.85 |
| 15 | 61 | 1 | Lobular | 2.3 | 2 | Positive | 0.89 | -1.88 | -1.61 | -0.94 |
| 16 | 73 | 22 | Ductal | 1.9 | 2 | Negative | 0.98 | -1.28 | -0.34 | 0.26 |
| 17 | 58 | 3 | Ductal | 9.0 | 2 | Positive | 0.96 | -0.48 | 0.26 | -0.42 |
| 19 | 68 | 13 | Ductal | 1.2 | 1 | Negative | 0.97 | -2.18 | -2.62 | 0.31 |
| 18a | 67 | 11 | Ductal | 1.5 | 2 | Micrometastasis | NA | NA | NA | NA |
| 20 | 44 | 13 | Ductulo-lobular | 3.2 | 3 | Positive | 0.98 | -0.12 | 0.01 | 0.19 |
| 21 | 71 | 20 | Ductulo-lobular | 1.7 | 3 | Negative | 0.95 | -3.15 | -1.69 | 0.26 |
| 22 | 53 | 5 | Ductal | 1.3 | 2 | Negative | 0.92 | -2.81 | -5.48 | -0.08 |
aRNA in the core biopsy (CB) of this patient was degraded and, therefore, omitted from the study. COX, cyclooxygenase; NA, not available; PAI-1, Plasminogen Activator Inhibitor-1; ST, surgical tumor tissue specimen.