Table 3.
List of 80 genes able to discriminate between poorly differentiated DCIS and invasive grade 3 breast tumours
| Rank | NKI ID | Symbol | Annotation | Accession no. |
| 1 | 123776 | PIAS4 | Protein inhibitor of activated STAT protein | H30547 |
| 2 | 129658 | MGC13045 | DnaJ (Hsp40) homolog, subfamily C, member 4 | AA996059 |
| 3 | 121937 | FLJ10374 | Hypothetical protein FLJ10374 | AA676962 |
| 4 | 102847 | YIF1 | Putative transmembrane protein; homolog of yeast Golgi membrane protein Yif1p (Yip1p-interacting factor) | H79351 |
| 5 | 127755 | TGFB2 | Transforming growth factor, beta 2 | W47556 |
| 6 | 117289 | MMP11 | Matrix metalloproteinase 11 (stromelysin 3) | AA045500 |
| 7 | 104973 | SYNPO2 | Synaptopodin 2 | R31679 |
| 8 | 121066 | DAPK3 | Death-associated protein kinase 3 | AA973730 |
| 9 | 128493 | GMFG | Glia maturation factor, gamma | AI311932 |
| 10 | 105533 | ARF1 | ADP-ribosylation factor 1 | W45572 |
| 11 | 132031 | NY-REN-24 antigen | AA918005 | |
| 12 | 127881 | NFIC | Nuclear factor I/C (CCAAT-binding transcription factor) | T59427 |
| 13 | 120649 | KCTD5 | Potassium channel tetramerisation domain containing 5 | AA521027 |
| 14 | 120934 | EIF4G1 | Eukaryotic translation initiation factor 4 gamma, 1 | R37276 |
| 15 | 105453 | PSAP | Prosaposin (variant Gaucher disease and variant metachromatic leukodystrophy) | N72215 |
| 16 | 112695 | SYNPO2 | H. sapiens cDNA FLJ20767 fis, clone COL06986 | AA043349 |
| 17 | 101577 | BMI1 | Murine leukaemia viral (bmi-1) oncogene homolog | AA478036 |
| 18 | 105479 | BAT3 | HLA-B-associated transcript-3 | AA434416 |
| 19 | 123071 | C9orf82 | Hypothetical protein FLJ13657 | AA135972 |
| 20 | 101638 | ID4 | Inhibitor of DNA binding 4, dominant negative helix-loop-helix protein | AA464856 |
| 21 | 115306 | LRP16 | LRP16 protein | AA456318 |
| 22 | 118143 | STX1B2 | ESTs, moderately similar to ST1B_HUMAN SYNTAXIN 1B [H. sapiens] | H41572 |
| 23 | 128106 | DUSP6 | Dual specificity phosphatase 6 | AA455254 |
| 24 | 115676 | RPS15A | Ribosomal protein S15a | AA411682 |
| 25 | 108595 | CCL19 | Small inducible cytokine subfamily A (Cys-Cys), member 19 | AA680186 |
| 26 | 126589 | C6orf166 | Hypothetical protein FLJ10342 | AA984953 |
| 27 | 131540 | PRPF31 | DKFZP566J153 protein | AI253017 |
| 28 | 109065 | SYT5 | H39018 | |
| 29 | 128198 | MMP11 | Matrix metalloproteinase 11 (stromelysin 3) | AA954935 |
| 30 | 109364 | MYST2 | Histone acetyltransferase | H11938 |
| 31 | 106989 | TNFSF13 | Tumour necrosis factor (ligand) superfamily, member 13 | AA443577 |
| 32 | 109798 | T82459 | ||
| 33 | 131890 | CDH1 | Cadherin 1, type 1, E-cadherin (epithelial) | AI671174 |
| 34 | 111513 | COG3 | H. sapiens clone 25226 mRNA sequence | AA461166 |
| 35 | 108645 | HMGCS2 | 3-Hydroxy-3-methylglutaryl-Coenzyme A synthase 2 (mitochondrial) | AA496149 |
| 36 | 101651 | TRAP1 | Heat shock protein 75 | AA497020 |
| 37 | 105304 | LRP16 | LRP16 protein | W52182 | AA284285 |
| 38 | 105363 | ARL7 | ADP-ribosylation factor-like 7 | AA485683 |
| 39 | 127890 | PTMS | Parathymosin | AA458981 |
| 40 | 118682 | NBS1 | Nijmegen breakage syndrome 1 (nibrin) | H98655 |
| 41 | 108997 | PTTG1IP | Pituitary tumour-transforming 1 interacting protein | AA156461 |
| 42 | 110281 | HSPA1L | Heat shock 70-kD protein-like 1 | H17513 |
| 43 | 125700 | APC2 | Adenomatous polyposis coli like | AA976241 |
| 44 | 117139 | ALDOB | Aldolase B, fructose-bisphosphate | H72098 |
| 45 | 107595 | SOX17 | SRY-box 17 | AA427400 | AI732705 |
| 46 | 107375 | NUCKS | Similar to rat nuclear ubiquitous casein kinase 2 | AA137266 |
| 47 | 109238 | BSG | Basigin (OK blood group) | AA436440 |
| 48 | 122821 | NSE2 | ESTs | H30453 |
| 49 | 123689 | LOC339123 | STIP1 homology and U-Box containing protein 1 | R54844 |
| 50 | 115953 | LOC146542 | Human Chromosome 16 BAC clone CIT987SK-A-635H12 | AA455010 |
| 51 | 108960 | GABRD | H41122 | |
| 52 | 128222 | GLUL | Glutamate-ammonia ligase (glutamine synthase) | AI000103 |
| 53 | 100222 | NFIX | Nuclear factor I/X (CCAAT-binding transcription factor) | AA406269 |
| 54 | 105470 | ISYNA1 | Myo-inositol 1-phosphate synthase A1 | AA454554 |
| 55 | 117998 | RBM9 | RNA binding motif protein 9 | H03903 |
| 56 | 105404 | GDF15 | Prostate differentiation factor | N26311 |
| 57 | 127811 | TOB1 | Transducer of ERBB2, 1 | W96163 |
| 58 | 105524 | RPS6KA4 | Ribosomal protein S6 kinase, 90-kD, polypeptide 4 | AA443601 |
| 59 | 109232 | BCKDHA | Branched chain keto acid dehydrogenase E1, alpha polypeptide (maple syrup urine disease) | AA477298 |
| 60 | 115741 | APPL | Adaptor protein containing pH domain, PTB domain and leucine zipper motif | AA436158 |
| 61 | 100898 | ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific) | AA434373 |
| 62 | 101067 | MAP7 | Microtubule-associated protein 7 | R77252 | R77251 |
| 63 | 109306 | AQP1 | Aquaporin 1 (channel-forming integral protein, 28 kD) | H24316 |
| 64 | 102326 | CYC1 | Cytochrome c-1 | AA447774 |
| 65 | 108988 | MALAT1 | Histone deacetylase 3 | H88540 |
| 66 | 102253 | ACTG2 | Actin, gamma 2, smooth muscle, enteric | T60048 |
| 67 | 116834 | GPC1 | Glypican 1 | AA455896 |
| 68 | 105497 | HNRPK | Heterogeneous nuclear ribonucleoprotein K | W85697 |
| 69 | 108372 | LCP1 | Lymphocyte cytosolic protein 1 (L-plastin) | W73144 |
| 70 | 128634 | PRCP | Prolylcarboxypeptidase (angiotensinase C) | AI360366 |
| 71 | 106297 | PHF17 | Hypothetical protein FLJ22479 | AA136664 |
| 72 | 101616 | KRT19 | Keratin 19 | AA464250 |
| 73 | 128532 | LTB | Lymphotoxin beta (TNF superfamily, member 3) | AI351740 |
| 74 | 102385 | F13A1 | Coagulation factor XIII, A1 polypeptide | AA449742 |
| 75 | 102673 | WHSC1L1 | Wolf-Hirschhorn syndrome candidate 1-like 1 | T97900 |
| 76 | 109638 | CXXC1 | CpG binding protein | T60082 |
| 77 | 109116 | FBL | Fibrillarin | AA663986 |
| 78 | 109425 | TUBB | Tubulin, beta polypeptide | AA427899 |
| 79 | 117500 | EST | AA621138 | |
| 80 | 100656 | UBE2C | Ubiquitin carrier protein E2-C | AA430504 |
DCIS, ductal carcinoma in situ; EST, expressed sequence tag; NKI ID, Netherlands Cancer Institute (Amsterdam, The Netherlands) identification number.