Skip to main content
. Author manuscript; available in PMC: 2007 Jul 1.
Published in final edited form as: Ophthalmology. 2006 May 2;113(7):1187.e1–1187.12. doi: 10.1016/j.ophtha.2005.12.020

Table 1.

Comparison of Clinically Significant Macular Edema (CSME) and Diabetic Macular Edema (DME) Grading by Macular Grid 5 Analysis (MG5) versus the Clinician

MG5 vs. Clinical Examination*
CSME 1 CSME 2 Any CSME Any DME
Edema present on MG5 only  7  5  4  7
Edema present on clinical examination only  3  3  4  4
Both 22 25 31 37
None 31 30 24 15
κ (95% CI) 0.677 (0.495–0.860) 0.745 (0.580–0.910) 0.743 (0.577–0.909) 0.603 (0.393–0.814)
Agreement     0.841     0.873     0.873     0.825
Sensitivity (95% CI) 0.880 (0.677–0.968) 0.893 (0.706–0.972) 0.886 (0.723–0.963) 0.902 (0.759–0.968)
Specificity (95% CI) 0.816 (0.651–0.9168) 0.857 (0.690–0.946) 0.857 (0.664–0.953) 0.682 (0.451–0.853)

CI = confidence interval; CSME 1 = any retinal thickening within 500 μm of the foveal center; CSME 2 = retinal thickening within 1 Macular Photocoagulation Study (MPS) disc diameter (1.5 mm) of the foveal center and >1 MPS disc area in size. Sensitivity and specificity for MG5 are calculated with respect to the clinical gold standard.

*

Grading as assessed by biomicroscopy and/or stereo photography.

CSME 1 or 2 or lipid within 500 μm of the foveal center associated with adjacent retinal thickening.

Presence of any retinal thickening within the macula.