Table 1.

Comparison of Clinically Significant Macular Edema (CSME) and Diabetic Macular Edema (DME) Grading by Macular Grid 5 Analysis (MG5) versus the Clinician

	MG5 vs. Clinical Examination*
	CSME 1	CSME 2	Any CSME†	Any DME‡
Edema present on MG5 only	7	5	4	7
Edema present on clinical examination only	3	3	4	4
Both	22	25	31	37
None	31	30	24	15
κ (95% CI)	0.677 (0.495–0.860)	0.745 (0.580–0.910)	0.743 (0.577–0.909)	0.603 (0.393–0.814)
Agreement	0.841	0.873	0.873	0.825
Sensitivity (95% CI)	0.880 (0.677–0.968)	0.893 (0.706–0.972)	0.886 (0.723–0.963)	0.902 (0.759–0.968)
Specificity (95% CI)	0.816 (0.651–0.9168)	0.857 (0.690–0.946)	0.857 (0.664–0.953)	0.682 (0.451–0.853)

CI = confidence interval; CSME 1 = any retinal thickening within 500 μm of the foveal center; CSME 2 = retinal thickening within 1 Macular Photocoagulation Study (MPS) disc diameter (1.5 mm) of the foveal center and >1 MPS disc area in size. Sensitivity and specificity for MG5 are calculated with respect to the clinical gold standard.

^*Grading as assessed by biomicroscopy and/or stereo photography.

^†CSME 1 or 2 or lipid within 500 μm of the foveal center associated with adjacent retinal thickening.

^‡Presence of any retinal thickening within the macula.