Table 2. Characteristics of the study subjects according to the catechol-o-methyltransferase (COMT) genotypes^* .

Characteristic	COMT Val158Val (n = 172)	COMT Val158Met (n = 391)	COMT Met158Met (n = 229)	p-value
Serum tHcy, µmol/L	11.0±4.4	10.7±3.2	10.9±2.6	0.521
Serum folate, nmol/L	10.3±4.2	10.4±3.8	10.3±4.0	0.927
Age, y	55.4±6.6	54.9±6.4	56.1±7.0	0.086
BMI, kg/m2	27.4±3.5	27.3±3.5	27.9±3.7	0.147
Systolic blood pressure, mmHg	134±15	135±17	136±17	0.397
Total cholesterol, mmol/L	5.63±0.90	5.43±0.93	5.52±0.84	0.056
LDL cholesterol, mmol/L	4.02±0.80	3.85±0.83	3.93±0.76	0.060
HDL cholesterol, mmol/L	1.12±0.29	1.09±0.26	1.14±0.33	0.061
Triglycerides, mmol/L	1.55±0.87	1.57±0.98	1.58±1.23	0.944
Current smokers, %	26.9	26.6	27.1	0.991
IHD in family, %	53.5	47.3	52.8	0.262
Subjects who developed an acute coronary event, %	8.0	7.0	13.0	0.041

Abbreviations: BMI = body mass index; HDL = high density lipoprotein; IHD = ischemic heart disease; LDL = low density lipoprotein; tHcy = total homocysteine concentration.

^*Data are expressed as the mean±SD unless otherwise indicated.