Figure 4. Effects of deleting the Igf2 gene on placental nutrient transfer.

Ratios of mutant to wild-type placental transfer of [¹⁴C]glucose (A) and [¹⁴C]methyl-AIB (B) expressed per gram placenta in Igf2P0 and complete Igf2 null mice at day 16 and day 19 of gestation (Term 21 days). Bar 95% confidence limits. Ratio significantly different from 1: ***P < 0.001 **P < 0.01 *P < 0.05. n = 11 litters for each marker at each age. Data from Constancia et al. (2002, 2005).