Table 6.
Expression profiles of genes encoding ubiquitin-mediated proteolysis and cell cycle genes
| Gene name | Gene ID | Fold change | Direction of change |
|---|---|---|---|
| Beta-transducin repeat containing | BTRC | 1.41 | Up |
| Cyclin B1 | CCNB1 | 1.35 | Down |
| Cyclin G2 | CCNG2 | 1.55 | Down |
| Cyclin-dependent kinase inhibitor 3 | CDKN3 | 1.31 | Up |
| Chromodomain helicase DNA BP3 | CHD3 | 1.54 | Down |
| Connective tissue growth factor | CTGF | 1.63 | Down |
| Cullin 4B | CUL4B | 1.61 | Up |
| Cullin 4B | CUL4B | 1.61 | Up |
| Dynactin 1 | DCTN1 | 1.28 | Down |
| Damage-specific DNA BP1 | DDB1 | 1.24 | Up |
| E1A binding protein p300 | EP300 | 1.26 | Down |
| Exostoses 2 | EXT2 | 1.38 | Down |
| F-box protein 21 | FBXO21 | 1.19 | Down |
| F-box protein 38 | FBXO38 | 1.47 | Down |
| F-box protein 42 | FBXO42 | 1.26 | Down |
| F-box protein 7 | FBXO7 | 1.22 | Down |
| F-box and WD-40 domain protein 11 | FBXW11 | 1.72 | Up |
| Growth arrest-specific 1 | GAS1 | 1.35 | Down |
| HECT, C2 and WW domain E3 ubiquitin pro lig 1 | HECW1 | 1.47 | Up |
| Katanin subunit A 1 | KATNA1 | 1.26 | Down |
| KH domain containing, RNA bind, sig trans 1 | KHDRBS1 | 1.49 | Down |
| Karyopherin alpha 2 | KPNA2 | 1.46 | Down |
| Ring finger protein 187 | LOC149603 | 1.49 | Down |
| Mitogen-activated protein kinase 7 | MAPK7 | 1.59 | Down |
| Membrane-associated ring finger 6 | MARCH-VI | 1.47 | Down |
| Minichromosome maintenance deficient 6 | MCM6 | 1.18 | Down |
| Makorin, ring finger protein, 1 | MKRN1 | 1.21 | Down |
| Nuclear protein localization 4 | NPL4 | 1.71 | Down |
| Nuclear distribution gene C | NUDC | 1.35 | Down |
| Polymerase epsilon 3 | POLE3 | 1.44 | Down |
| Protein phosphatase 1a | PPP1CA | 1.51 | Down |
| Protein phosphatase 1b | PPP1CB | 1.41 | Down |
| Protein phosphatase 1 g | PPP1CC | 1.26 | Down |
| PRP19/PSO4 premRNA processing factor 19 | PRP19 | 1.29 | Down |
| Protein tyrosine phosphatase IVA1 | PTP4A1 | 1.42 | Up |
| RNA binding motif protein 5 | RBM5 | 1.59 | Down |
| Ring-box 1 | RBX1 | 1.44 | Down |
| Ras homologue gene family, member B | RHOB | 1.50 | Down |
| Ring finger protein 103 | RNF103 | 1.33 | Down |
| Ring finger protein 111 | RNF111 | 1.41 | Down |
| Ring finger protein 34 | RNF34 | 1.19 | Down |
| Ring finger protein 4 | RNF4 | 1.65 | Down |
| SET translocation (myeloid leukaemia-associated) | SET | 1.45 | Down |
| Seven in absentia homologue 1 (Drosophila) | SIAH1 | 1.30 | Down |
| Structural maintenance chromosomes 4L1 | SMC4L1 | 1.77 | Up |
| Stromal antigen 2 | STAG2 | 1.82 | Up |
| STIP1 homology, U-box containing protein 1 | STUB1 | 1.29 | Down |
| Suppressor of mif two 3 homologue 2 | SUMO2 | 1.33 | Down |
| Transcription elongation factor B1 | TCEB1 | 1.56 | Down |
| Tousled-like kinase 1 | TLK1 | 1.35 | Down |
| Tumor suppressor candidate 4 | TUSC4 | 1.69 | Down |
| Ubiquitin-conjugating enzyme E2E3-UBC4/5 homologue | UBE2E3 | 1.49 | Down |
| Ubiquitin specific protease 4 | USP4 | 1.22 | Down |
| Ubiquitin specific protease 46 | USP46 | 1.34 | Down |
| Wilms tumour 1 | WT1 | 2.01 | Down |
| Kinetochore associated homologue | ZW10 | 1.22 | Down |
Genes previously identified that encode components of ubiquitin-mediated proteolysis and cell cycle pathways and shown to be differentially expressed in 90 dG kidneys from fetuses of nutrient restricted mothers versus controls are listed. ‘Gene ID’ indicates the assigned gene identification, ‘Fold change’ indicates the fold change between fetal kidneys from C and NR mothers, and ‘Direction of change’ indicates the direction of change for NR kidney RNA compared with C kidney RNA.