Figure 1. Schematic representation of the experimental design.

There were three experimental groups in which saline (sham), WY 14,643 or Rosiglitazone were infused continuously for 7 days, using an implanted mini-osmotic pump. In addition, in each animal, EDL muscles in one leg were induced to contract for up to 7 days while the contralateral EDL was not stimulated (rest). The animals were killed after 1,3,5 and 7 days of treatment.