Data are means ± s.e.m. n = 4 – 5 muscles for each group at each data point. *P < 0.05, chronic contraction versus day 0. **P < 0.05, chronic contraction + rosiglitazone versus day 0. ***P < 0.05, chronic contraction + Wy 14,643 versus day 0. †P < 0.05, chronic contraction + Wy 14,643 versus chronic contraction, and chronic contraction + Wy 14,643 versus chronic contraction + rosiglitazone.