Skip to main content
. 2006 Mar 31;573(Pt 2):453–468. doi: 10.1113/jphysiol.2006.107375

Figure 3. Net outward current density in OVX mice by chronic injection of 17β-oestradiol and progesterone.

Figure 3

To examine the effect of elevating circulating levels of oestrogen in OVX mice, 17β-oestradiol (OES) was injected into OVX mice for 7 days. Outward currents were recorded from colonic myocytes from three animal groups: OVX (A), OVX with OES (B) and non-pregnant females (C). Outward current density in OVX with OES and non-pregnant females was lower than OVX mice (D and F, P < 0.05 at test potentials > +30 mV). Current densities between non-pregnant female and OVX with OES treatment were not significantly different at any test potentials tested (E). To examine chronic effects of progesterone on outward currents, current density was compared between three animal groups: OVX (G) and OVX which had received progesterone (PGT) injections for 7 days (H). Current density in OVX with PGT treatment was not significantly different from OVX mice (I).