Figure 4. Net outward currents are reduced during the last trimester of pregnancy.

To assess the effects of pregnancy on outward currents in colonic myocytes comparisons were made between non-pregnant females (A) and pregnant mice in the first trimester (Early; B) and last trimester (Late; C) of pregnancy. Current density in late pregnancy was significantly reduced compared with non-pregnant females and those in the early stage of pregnancy (D). Voltage dependence of activation and inactivation were not affected by pregnancy (E).