Figure 9. Lack of effect of 1 mm orthovanadate on either the degree of stimulation of IKs by 1 μm forskolin, or the half-time of decay of stimulation following the removal of forskolin.
A, example of stimulation and decay of IKs in a control myocyte treated with forskolin (FSK). B, example of stimulation and decay of IKs in a myocyte pretreated with orthovanadate (Van) and subsequently cotreated with forskolin. C, comparison of the degree of stimulation of IKs induced by forskolin in control and orthovanadate-pretreated myocytes. D, comparison of the half-times of decay of forskolin-induced stimulation upon withdrawal of forskolin ((–)FSK) in control and orthovanadate-pretreated myocytes. Number of myocytes is shown in parentheses.