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. 2006 Apr 6;573(Pt 2):357–370. doi: 10.1113/jphysiol.2006.109967

Figure 2. The src-PTK inhibitor PP2 abolishes the hypoxic inhibition of Kv1.3 channels in primary T lymphocytes.

Figure 2

A, representative Kv1.3 ensemble average currents (from 50 consecutive traces) recorded in cell-attached patch-clamp experiments during 900 ms long step depolarizing pulses from −80 mV HP to +50 mV in normoxia and after 3 min hypoxia in the presence of either 50 nm PP2 (left panel) or PP3 (right panel). CD4+ lymphocytes were preincubated with PP2/PP3 for 20 min before electrophysiological experiments and PP2/PP3 was maintained thereafter throughout the entire experiment. Leak and capacitative currents were subtracted from the record. Dashed lines represent the zero current. B, the corresponding average NPo values in normoxia and hypoxia in the presence of PP2 (n = 13) and PP3 (n = 6).