Table 1.
Characterization of anti-PrP Mabs
| Antibody | Antigen localization† | KD |
|---|---|---|
| 7D9 | Unknown, nonlinear | 8.2 ± 0.19 × 10−10M |
| 8B4 | 35–45 | 2.4 ± 0.60 × 10−10M |
| 6D11 | 93–109 | 8.5 ± 0.18 × 10−11M |
| 11G5 | 115–130 (1st β-strand) | 5.4 ± 0.17 × 10−10M |
| 7H6 | 130–140 | 2.2 ± 0.04 × 10−10M |
| 7A12 | 143–155 (α-helix A) | 1.9 ± 0.05 × 10−10M |
| 2C2 | 153–165 (2nd β-strand) | 3.4 ± 0.15 × 10−9M |
| 8H4 | 175–185 (α-helix B) | 3.8 ± 0.11 × 10−10M |
| 9H7 | 143–231 | 10.3 ± 0.43 × 10−10M |
| 8F9 | 220–231 | 10.6 ± 0.50 × 10−9M |
†
Numbers correspond to residues of murine PrP. KD values are given as mean ± SD from at least three independent experiments.