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. 2006 Sep 22;91(12):4565–4574. doi: 10.1529/biophysj.105.080457

FIGURE 2.

FIGURE 2

(a) In situ TMAFM topography (height) image of Tet C adsorbed on a mica surface. Cross section analysis found the Tet C molecules to have a height of ∼3.5 nm and widths of 9–32 nm. The AFM image is height-encoded by color where lighter colors correspond to taller features. Height scale, 20 nm; scale bar, 500 nm. (b) Electrostatic potential surface maps of the Tet C crystal structure oriented at Tet C is believed to interact with the mica surface. Based on these structures, Tet C is believed to adsorb onto the mica surface as single molecules and in an orientation similar to that with which it binds to the GT1b receptor. (red, areas of negative charge; blue, areas of positive charge.) Images are based on PDB model 1FV2 and prepared using the Swiss PDB Viewer molecular graphic software package (GlaxoSmithKline).