FIGURE 3.

(a) Biological construct. (b) Histogram of the signals for 5-nm gold NPs detected on COS7 cells. (c) LISNA image of a portion of a transfected COS7 cell labeled with 5-nm gold NPs detected with a SNR ∼30. Moving NPs during the raster scan of the sample produce characteristic stripe signals. Lines are trajectories recorded with single receptors diffusing on the cell membrane. (d) Zoom onto one recorded trajectory. (e) Time trace of the signal amplitude calculated from the triangulation process while tracking one of those NP. Increased signal fluctuations correspond to the NP in a fast diffusive state.