TABLE 2.
Myofibril statistics of pwMhc2 positive control and two 15b trangenics
| Sarcomere stiffness (nN/nm)* | Diameter (μm)* | Stiffness/CSA‡ (nN/nm/μm2)* | Initial SL (μm)* | Elastic modulus§ (nN/μm2)* | Corrected elastic modulus¶ (nN/μm2)* | n | |
|---|---|---|---|---|---|---|---|
| pwMhc2 | 0.849 ± 0.023 | 1.88 ± 0.04 | 0.308 ± 0.012 | 3.61 ± 0.10 | 1114 ± 52 | 646 ± 30 | 9 |
| 15b-47 | 0.692 ± 0.018† | 1.68 ± 0.03† | 0.314 ± 0.011 | 3.95 ± 0.10† | 1245 ± 68 | 722 ± 39 | 9 |
| 15b-108 | 0.729 ± 0.019† | 1.78 ± 0.03† | 0.293 ± 0.015 | 3.81 ± 0.04 | 1115 ± 58 | 647 ± 34 | 8 |
| p-value | 0.004 | 0.000 | 0.502 | 0.031 | 0.226 | 0.226 |
*
Values are mean ± SE.
†
Indicates values are significantly different (p < 0.05) from the hinge-switch positive control, pwMhc2.
‡
Stiffness/CSA = sarcomere stiffness / (π × (diameter/2)2).
§
Elastic modulus = (stiffness / CSA) × initial SL.
¶
Corrected elastic modulus = 0.58 × elastic modulus.