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. 2006 Dec 6;39(6):145–153. doi: 10.1267/ahc.06023

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Copyright © 2006 AHC

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fig. 4 — Neurokinin 1 receptor (NK1R) internalization of ICC-DMP in the murine small intestine. A, B: ICC-DMP expressing NK1R (green) are in close contact with substance P (red) containing nerve terminals (arrows). CM and LM indicate circular muscle and longitudinal muscle layers, respectively. C: Experimental scheme of electrical field stimulation (EFS). Musculature between the parallel platinum electrodes is stimulated by EFS (10 Hz, 0.5 ms duration, 15V) for 1 min. Stimulated nerve terminals release neurotransmitters such as substance P. ICC-DMP near the nerve terminals receive substance P and substance P-NK1R complexes are internalized into the cell bodies. D, E: NK1R (green) distribution in ICC-DMP before and after nerve stimulation. Before stimulation (D), NK1R are distributed around the peripheries of ICC-DMP. After EFS (E), NK1R are concentrated into granular structures (arrowheads) in ICC-DMP. Bars=20 µm (A, D, E), 50 µm (B).