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. 2006 Mar 2;572(Pt 3):789–798. doi: 10.1113/jphysiol.2006.105510

Figure 2. Differential sensitivity of P-ERK to reduction of NMDA current through extrasynaptic and entire pool of NMDARs.

Figure 2

A, currents induced by bath activation of 10 μm NMDA before and after block of the synaptic NMDARs with MK-801 (entire NMDA and extrasynaptic NMDA, respectively). B, dose dependence of the inhibition of NMDA (10 μm)-induced currents by d-AP5. n = 7. Example shows current recorded during application of 10 μm NMDA and NMDA with 10 μm D-AP5. C, inhibition of the NMDAR with 20 μmd-AP5 does not affect the NMDA-induced ERK phosphorylation. Neurons were incubated with indicated agonists and blockers for 5 min. Mean ± s.e.m. from 5 experiments.