Figure 4. The ClC-2 inhibitor Cd²⁺does not affect swelling-activated d-[³H]aspartate release and Cl⁻ currents.

A, effect of Cd²⁺ on swelling-activated d-[³H]aspartate release. Cells were exposed to hypoosmotic medium for 10 min, as indicated, in the presence (□) or absence (▪) of 300 μm Cd²⁺. Data are means ± s.e.m. of 5–6 experiments. NS, not significant (P = 0.294), Cd²⁺versus control, repeated measures ANOVA. B, effect of 300 μm Cd²⁺ on swelling-activated Cl⁻ currents. Representative of 6 electrophysiological recordings.