Figure 13. Effect of spermine on the firing mode of TC neurons.

Representative whole-cell current-clamp recording from a TC neuron; the membrane potential was adjusted to −73 mV by constant current injection. The measurements were performed in normal ACSF containing 2 mm Ca²⁺ and 2 mm Mg²⁺. A, firing pattern produced by injection of a depolarizing current pulse before application of spermine. B, firing pattern produced by injection of the same current pulse (superimposed on the same hyperpolarizing holding current) 4 min after application of spermine (500 μm).