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. 2007 Jan 22;104(5):1604–1609. doi: 10.1073/pnas.0610731104

Fig. 3.

Fig. 3.

TLRs induce miR-155 expression through MyD88- or TRIF-dependent signaling pathways. (A) WT (Wt) murine macrophages were stimulated with medium (m), 2 μg/ml poly(I:C) [p(I:C)], 5 ng/ml LPS, 2 μg/ml Pam3CSK4 (P3C), or 100 nM CpG for 6 h and assayed by Northern blot analysis with a miR-155-specific probe. (B) WT, MyD88−/−, or TRIF−/− macrophages were stimulated with medium, poly(I:C), LPS, CpG, or Pam3CSK4 for 6 h, and miR-155 expression was assayed by qPCR. (C) WT or IFNAR−/− macrophages were stimulated with medium, poly(I:C), LPS, CpG, or Pam3CSK4 for 6 h, and miR-155 expression was assayed by qPCR.