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Pharmacological inhibition of JNK blocks poly(I:C) and TNF-α induction of miR-155. WT murine macrophages were pretreated for 30 min with DMSO or sp600125 at 5 or 25 μg/ml and subsequently stimulated with medium, 2 μg/ml poly(I:C), or 10 ng/ml TNF-α in the presence of the vehicle or inhibitor. After 4 h, RNA was collected, and miR-155 expression was assayed by qPCR.
