Figure 2.

Effects of a monoclonal antibody to human amphiregulin on epidermal thickness of human nonpsoriatic skin transplanted to SCID mice. Top: Histological appearance. A: After transplantation and treatment with anti-amphiregulin; B: after transplantation and treatment with a control antibody. Bottom: Quantitative measurements. Values shown are means and SDs based on four to six measurements per histological section in four histological sections per mouse from duplicate mice transplanted with skin samples from four nonpsoriatic donors. Differences between groups were analyzed for statistical significance using the Student’s t-test. *, Difference from control antibody at P < 0.01 level.