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. Author manuscript; available in PMC: 2007 Jan 23.
Published in final edited form as: Brain Res. 2005 Dec 20;1069(1):172–181. doi: 10.1016/j.brainres.2005.11.005

Fig. 4.

Fig. 4

Antidepressant-like effect of JOM-13 in the forced swim test. (a) 32 mg/kg JOM-13, i.v., produced a significant decrease in immobility in the forced swim test, indicating an antidepressant-like effect, and significantly increased swimming behavior (n = 6 per group). (b) 10 mg/kg NTI given 30 min prior to 32 mg/kg JOM-13 blocked the antidepressant-like effect (n = 5 per group). (c) 32 mg/kg produced convulsions in 2 out of 6 rats (33.33%). (d) When 10 mg/kg NTI was given as a pretreatment, no convulsions were observed with administration of 32 mg/kg JOM-13. *P < 0.05, **P < 0.01.