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. Author manuscript; available in PMC: 2007 Dec 1.
Published in final edited form as: Neuropsychopharmacology. 2006 May 3;31(12):2580–2590. doi: 10.1038/sj.npp.1301085

Figure 4.

Figure 4

The effects of 32 mg/kg antalarmin (n = 9) on HR (a) and PR interval (b) and the blockade of these effects after administration of 3.2 mg/kg methylatropine nitrate (mATR; n = 9). 100% of ECG implanted rats treated with 32 mg/kg antalarmin sank during the 2-hour swim test, whereas the addition of mATR blocked the behavioral effect of sinking in all antalarmin-treated rats. The cardiovascular effects of 20 mg/kg RU486 (n = 9) on HR (c) and PR interval (d) compared with vehicle-treated rats (n = 12) during swim exposure are also depicted. As previously mentioned, half of vehicle-treated rats sank, whereas no RU486-treated ECG rats sank. Baseline (BL) HR and PR interval were collected subsequent to drug or vehicle treatment while each rat was in its homecage, just prior to swim stress. Swim began at time zero, and data collection continued until sinking or the end of the 2 h swim. ↑ indicates when each antalarmin-treated rat sank.