TABLE 1.
Results of Visual Evoked Potentials (VEPs) and Electroretinograms (ERGs) Obtained on Days 1 and 8 of MOG-EAE (EAEd1 or EAEd8) in GA-Treated Animals and the Corresponding Control Group
| VEP EAEd1 flash | VEP EAEd8 flash | VEP EAEd1 pattern | VEP EAEd8 pattern | ERG EAEd1 flash | ERG EAEd8 flash | ERG EAEd1 pattern | ERG EAEd8 pattern | |
|---|---|---|---|---|---|---|---|---|
| Pretreatment | 6/8 | 8/8 | 0.56 ± 0.12 cyc/°* | 0.38 ± 0.06 cyc/°* | 8/8 | 8/8 | 0.51 ± 0.1 cyc/°* | 0.42 ± 0.08 cyc/°* |
| Early therapy | 6/8 | 2/8 | 0.26 ± 0.06 cyc/°* | 0.13 cyc/° | 8/8 | 7/8 | 0.3 ± 0.04 cyc/°* | 0.16 ± 0.01 cyc/° |
| Late therapy | 3/8 | 1/8 | − | − | 8/8 | 6/8 | − | − |
| Vehicle | 3/8 | 1/8 | − | − | 6/8 | 6/8 | − | − |
| Control: CFA-immunized | 8/8 (day 18 p.i.) | 1.31 ± 0.16 cyc/°† (day 18 p.i.) | 8/8 (day 18 p.i.) | 1.10 ± 0.13 cyc/°† (day 18 p.i.) |
Statistically significant when compared with vehicle-treated animals (P < 0.05).
Statistically significant when compared with GA-treated animals (P < 0.05).
Control rats immunized with CFA were measured on day 18 after immunization (p.i.) as described previously.16 The number of eyes with detectable potentials to flash stimulation is given as the number of total tested eyes in each group (x/8). The results from pattern stimulation are given as visual acuity values calculated from VEP or ERG amplitudes and the spatial frequency of the pattern stimulation. −, Indicates groups with no detectable responses to pattern stimulation or values less than 0.13 cycle/degree (cyc/°) (which is the threshold of visual acuity detectable by this method).