Table 2-6991.
Results of Visual Evoked Potentials (VEPs) and Electroretinograms (ERGs) Obtained on Days 1 and 8 of MOG-EAE (EAEd1 or EAEd8) in IFN-β-1b-Treated Animals and the Corresponding Control Group
| VEP EAEd1 flash | VEP EAEd8 flash | VEP EAEd1 pattern | VEP EAEd8 pattern | ERG EAEd1 flash | ERG EAEd8 flash | ERG EAEd1 pattern | ERG EAEd8 pattern | |
|---|---|---|---|---|---|---|---|---|
| Pretreatment | 5/8 | 4/8 | 0.18 ± 0.03 cyc/° | − | 6/8 | 4/8 | 0.16 ± 0.02 cyc/° | − |
| Early therapy | 4/8 | 2/8 | − | − | 5/8 | 3/8 | − | − |
| Late therapy | 4/8 | 1/8 | − | − | 5/8 | 2/8 | − | − |
| Vehicle | 5/8 | 2/8 | − | − | 7/8 | 3/8 | − | − |
| Control: CFA-immunized | 8/8 (day 18 p.i.) | 1.31 ± 0.16 cyc/°* (day 18 p.i.) | 8/8 (day 18 p.i.) | 1.10 ± 0.13 cyc/°* (day 18 p.i.) |
*
Statistically significant when compared with IFN-β-1b-treated animals (P < 0.005). Control rats immunized with CFA were measured on day 18 after immunization (p.i.) as described previously.16