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. 2006 Oct;169(4):1390–1401. doi: 10.2353/ajpath.2006.060005

FIGURE 1.

FIGURE 1

Immunodetection of MMP-3 in the nuclei of hepatocytes in human liver. A: Immunostaining of a HCC section in a cirrhotic patient shows staining in a majority of tumor cells. B: Immunostaining of the peritumoral part of the same patient shows a much lighter staining than in the tumor. C: Immunostaining of a HCC section in a noncirrhotic patient shows staining in a majority of tumor cells. D: Immunostaining of the peritumoral part of the same patient does not show any nuclear staining. E: Immunoelectron microscopy: several tumoral hepatocytes show a nuclear labeling for MMP-3. F: Higher magnification of the zone delimited in E. G: Negative control for immunoelectron microscopy with a control rabbit IgG. H: Higher magnification of the zone delimited in G clearly shows the lack of any nuclear staining.