TABLE 1.
Inhibition of Erbb2 and UV Exposure Alters the Expression of Genes Involved in Various Biological Processes
| Biological process | Sham
|
6 hours after UV
|
24 hours after UV
|
Total* | |||
|---|---|---|---|---|---|---|---|
| ↓ | ↑ | ↓ | ↑ | ↓ | ↑ | ||
| Proliferation | 3† | 2 | 6 | 21 | 3 | 6 | 36 (10%)‡ |
| Apoptosis | 2 | 2 | 6 | 5 | 4 | 6 | 25 (7%) |
| Immune response | 0 | 8 | 42 | 3 | 14 | 4 | 65 (18%) |
| Adhesion and migration | 0 | 7 | 13 | 14 | 14 | 4 | 47 (13%) |
| Cancer | 3 | 5 | 12 | 25 | 7 | 8 | 55 (15%) |
| Metabolism | 10 | 9 | 23 | 63 | 24 | 43 | 158 (44%) |
| Development | 2 | 6 | 8 | 26 | 12 | 4 | 55 (15%) |
| Pigment biosynthesis | 3 | 0 | 0 | 5 | 0 | 1 | 6 (2%) |
| Cell communication | 1 | 6 | 18 | 18 | 20 | 5 | 65 (18%) |
| Total genes | 14 | 25 | 85 | 133 | 59 | 68 | 361 |
*
Note that because the expression of some genes is changed at multiple times, the total may not reflect the sum of the individual time points.
†
Number of genes increased (↑) or decreased (↓) in AG825-treated samples compared with the vehicle alone.
‡
Numbers in parentheses indicate the percentage of the total number of genes altered by Erbb2 for each biological process.