TABLE 5.

Effects of Continuous Subcutaneous Infusion of VEGF on Wound Closure in EP3^−/− Mice

Treatment	Vehicle (n = 6)	VEGF (n = 6)
Day 2	84.5 ± 3.3	60.8 ± 2.6*
Day 3	69.6 ± 4.0	42.5 ± 2.1*
Day 4	57.0 ± 4.9	30.8 ± 2.5*
Day 7	39.7 ± 5.1	12.9 ± 1.0*

Surgical wounds were made on the backs of EP3^−/− mice, and wound closure was determined as described in Materials and Methods. VEGF was subcutaneously infused (1 μg/day) with a mini-osmotic pump, and 1 day after the pump implantation, surgical wounds were made. Vehicle solution (physiological saline) was infused with the same pump. Data are means ± SEM for the indicated number of wounds (n). 

^*P < 0.01 (compared with vehicle-treated mice at the same day).