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. 2006 Nov;169(5):1812–1820. doi: 10.2353/ajpath.2006.060480

Figure 1.

Figure 1

Up-regulation of the components of the miR machinery in prostate cancer. A: Schematic representation of miR maturation. Up-regulated genes are underlined. B: Up-regulation of genes encoding miR machinery components in metastatic prostate adenocarcinoma. The fold change over organ-confined prostate adenocarcinoma is shown. POLR2A, polymerase (RNA) II polypeptide A; XPO5, exportin 5; EIF2C2, eukaryotic translation initiation factor 2C (Ago2); HSPCA, heat shock 90-kd protein 1, alpha; TNRC6B, trinucleotide repeat containing 6B; MOV10, Moloney leukemia virus 10, homolog; EIF2C1, eukaryotic translation initiation factor 2C1 (Ago1). C: Dicer mRNA and EIF2C2 mRNA levels in organ-confined and metastatic PCa (P < 0.05) assessed by gene array. Representative cases are shown.