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4-TBP induces oxidative stress in melanocytes. Normal human melanocytes (a, b) were dosed with 250 μmol/L 4-TBP for (c) 30 minutes and (d) 60 minutes. Cells were labeled with a nonfluorescent dye that is oxidized on contact with ROS and emits a green fluorescence. a and b represent phase-contrast and fluorescence images, respectively, of the same cells. ROS concentrations, indicated by fluorescence, increased with 4-TBP incubation times.
