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. 2006 Nov;169(5):1833–1842. doi: 10.2353/ajpath.2006.060234

Figure 2.

Figure 2

Inhibition of CaMKII on Fas-mediated apoptosis in cholangiocarcinoma cells. A: Cholangiocarcinoma cells were preincubated with or without KN-93 (10 μmol/L) for 30 minutes and subsequently exposed to Fas-activating antibody (CH-11, 500 ng/ml) for 24 hours at 37°C. Results shown are from four independent experiments performed in duplicate. B: Fas-resistant cells were preincubated without (C) or with KN-93 (10 μmol/L) for 30 minutes and subsequently exposed to Fas-activating antibody (CH-11) for 24 hours. Representative blots for CaMKII, pAKT, and FLIP of four independent experiments are shown.