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Scid Mice Groups
| Group | HT1080 cells, stably transfected | Number of animals | Doxycycline treatment |
|---|---|---|---|
| 1 | Empty plasmid | 8 | − |
| 2 | Empty plasmid | 8 | + |
| 3 | CD97 (EGF 1,2,5) | 8 | − |
| 4 | CD97 (EGF 1,2,5) | 8 | + |
| 5 | CD97 (EGF 1,2,5/TM1) | 8 | − |
| 6 | CD97 (EGF 1,2,5/TM1) | 8 | + |
| 7 | CD97 (EGF 1-5) | 8 | − |
| 8 | CD97 (EGF 1-5) | 8 | + |
All animals underwent a subcutaneous injection with different tet-off HT1080 stably transfected clones. Every second animal group received doxycycline every third day to maintain down-regulation of CD97.
