Figure 4.
A and B: The length of PGP 9.5-positive (A) or CGRP-positive (B) nerve fibers in ears examined 48 hours after hapten challenge in OX-sensitized C57BL/6 wild-type (vehicle, n = 5; OX, n = 10), TNF−/− mice (vehicle, n = 5; OX, n = 10), mast cell-deficient KitW-sh/W-sh mice (vehicle, n = 5; OX, n = 10), and KitW-sh/W-sh mice that had been selectively repaired of their mast cell deficiency by the intradermal injection of wild-type or TNF−/− BMCMCs (vehicle, n = 5; OX, n = 9 in each group). These mice are from the same groups shown in Figure 2. Data show the length of nerve fibers at 48 hours after OX or vehicle challenge in OX-sensitized mice. +, ++ = P < 0.05, P < 0.01 versus corresponding values for vehicle-treated ears; *, **, ***, **** = P < 0.05, P < 0.01, P < 0.001, P < 0.0001 for the comparisons indicated by brackets (Student’s t-test, two-tailed).