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Significantly impaired antigen-specific TH2 development in CD4+ T-cell-specific IL-4Rα-deficient mice is accompanied by polarized TH1. Splenocyte stimulation with SEA (10 μg/ml) for 72 hours and measurement of cytokine levels, IL-4 (A), IL-13 (B), and IFN-γ (C), in supernatants as determined by ELISA. Data shown are mean ± SD from five individual mice and are representative of three independent experiments.
