Figure 2.

Total body weight and submandibular gland weight of rats. Measurements were obtained 40 and 90 days after 17.5-Gy IR of head and neck. A: Changes of total body weight during experimental periods. Radiation significantly reduced body weight of animals, and amifostine significantly prevented the loss of body weight induced by IR. B: The weights of submandibular glands. HSP25 and amifostine significantly attenuated the loss of glandular weight compared with each controls. Differences of body weight and glandular weight, compared with controls, are indicated by •, compared with normal control; ♦; compared with vector transferred control; ▾, compared with vector transferred IR control; and ▿, compared with radiation control (P < 0.05).