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. 2006 Nov;169(5):1601–1611. doi: 10.2353/ajpath.2006.060327

Figure 4.

Figure 4

Quantitative analysis of apoptotic cell, active caspase-3, and cleaved PARP. A: Apoptotic index of different cell types (mean ± SD) in control and irradiated submandibular gland at 1 day, 40 days, and 90 days after IR. •, compared with normal control; ♦, compared with vector transferred control; ▾, compared with vector transferred IR control; and ▿, compared with radiation control denote statistical significance of P < 0.05. B: Immunoblot of active caspase-3 and cleaved PARP in damaged submandibular gland at 1 day after 17.5-Gy IR. Activation of caspase-3 and PARP by radiation was inhibited in HSP25-, HSP70i-, and amifostine-pretreated salivary gland. Representative image of two independent animals from each group is shown.