Table 1.
Effect of E2 on the Body Weight, Uterine Weight, Reendothelialization Process (D3 and D5 after Injury), and Circulating EPC in Ovariectomized Fgf2+/+ or Fgf2−/− Mice
| Fgf2+/+ placebo n = 8 | Fgf2+/+ E2n = 8 | Fgf2−/− placebo n = 8 | Fgf2−/− E2n = 8 | Two-factor ANOVA FGF2
|
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|---|---|---|---|---|---|---|---|
| E2 | Genotype | Interaction | |||||
| Body weight (g) | 19.2 ± 0.4 | 17.6 ± 0.5 | 20.3 ± 0.3 | 20.9 ± 0.6 | NS | NS | NS |
| Uterine weight (mg) | <20 | 134.4 ± 10.2 | <20 | 140.6 ± 12.4 | |||
| % of reendothelialization at D3 | 23.4 ± 2.1 | 38.8 ± 1.6* | 22.8 ± 2.5 | 21.7 ± 2.0 | <0.001 | ||
| EPC in blood (% of control) | 95 ± 7 | 184 ± 22* | 106 ± 16 | 98 ± 7 | 0.002 | ||
| % of reendothelialization at D5 | 53.1 ± 3.2 | 79.1 ± 4.4* | 52.1 ± 4.5 | 49.1 ± 3.3 | <0.001 | ||
ANOVA, analysis of variance.
*
P < 0.05 versus respective control.