Table 2.
Effect of E2 on the Body Weight, Uterine Weight, Reendothelialization, and Circulating EPC in Ovariectomized Process in OvariectomizedFgf2−/− Grafted with Fgf2+/+ BM or Fgf2+/+ Grafted with Fgf2−/− BM Mice
| +/+ = >−/− Placebo n = 7 | +/+ = >−/− E2n = 7 | −/− = >+/+ Placebo n = 7 | −/− = >+/+ E2n = 7 | Two-factor ANOVA chimeric
|
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|---|---|---|---|---|---|---|---|
| E2 | Genotype | Interaction | |||||
| Body weight (g) | 22.6 ± 0.3 | 22.1 ± 0.8 | 20.1 ± 0.4 | 22.1 ± 0.6 | NS | NS | NS |
| Uterine weight (mg) | <20 | 136.6 ± 10.0 | <20 | 128.6 ± 7.8 | |||
| % of reendothelialization at D3 | 29.7 ± 1.5 | 47.9 ± 1.6* | 27.1 ± 1.6 | 30.8 ± 2.3 | <0.0001 | ||
| EPC in blood (% of control) | 24 ± 3 | 149 ± 64* | 27 ± 3 | 33 ± 12 | 0.04 | ||
The percentage of reendothelialization represents the ratio of the area remaining deendothelialized at D3 or D5 on the area initially deendothelialized.
ANOVA, analysis of variance.
*
P < 0.05 versus respective control.